Despite a win over Ghana, Uruguay crashed out of the World Cup on Friday.
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But the fielders turned their frustrations on the performance crew, who angrily followed them into the tunnel.
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Uruguay beat Ghana 2-0 in their final Group H match before the Round of 16
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But South Korea's win over Portugal dropped them from the tournament to third place.
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As the final whistle blew, Uruguay's bench players jumped the referees as they tried to leave the pitch.
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Players have been seen physically assaulting officials, with at least one yellow card being handed out.
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The referees were eventually kicked out but relentless players followed.
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Star striker Luis Suarez left the field in tears after watching helplessly from the bench as Uruguay fought back to score another goal in the second half, which would have put them ahead.
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South Korea advanced to the knockout stages for the first time since 2010, while Portugal advanced with their first group win since 2006.
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They will face the winners of Friday's Group G match.